A comparative study of interleukin ۶ and ۱۷ serum levels in patients undergoing coronary artery bypass surgery using off-pump and on-pump methods

Introduction: This study aims to investigate the role of coronary artery bypass graft (CABG) surgery by off-pump and on-pump methods in the severity of postoperative inflammation based on serum levels of interleukin ۶ (IL۶) and interleukin ۱۷ (IL۱۷). Methods: This is a cross-sectional study in which ۳۹ patients’ candidate for CABG were evaluated in terms of serum levels of IL۱۷ and IL۶ before and after surgery in two groups of off-pump and on-pump CABG. Results: Thirty-nine patients with an average age of ۶۳±۸.۹ in the on-pump group and ۵۹±۷.۷۴ in the off-pump group were evaluated. There was no significant difference between the two groups in terms of baseline information and underlying diseases. IL۶ serum level (p=۰.۲۴۹) was not significantly difference between the two groups. However, IL۱۷ serum level (p=۰.۰۱۲) demonstrated a significant difference between the two groups. Conclusion: In general, the results of this study showed that increased IL۶ serum level following coronary artery bypass was not different between the two methods of CABG surgery. Besides, IL۱۷ exhibited a significant difference between the two groupsi that it was reduced in on-pump group in after surgery. It can be due to special condition’s patients or low sample size of study. Moreover, the postoperative complications were not significantly different between the two groups. This valuable outcome contradicts the popular belief that the use of the CARDIO PULMONARY BYPASS (CPB) system stimulates the immune system and hence its application should be limited.

کلیدواژه ها:

off-pump ، on-pump ، interleukin ، CABG