The Relationship between the Level of Pregnancy-Associated Plasma Protein A and Placenta Size and Thickness
- سال انتشار: 1400
- محل انتشار: مجله بین المللی کودکان، دوره: 9، شماره: 4
- کد COI اختصاصی: JR_INJPM-9-4_010
- زبان مقاله: انگلیسی
- تعداد مشاهده: 468
نویسندگان
Assistant Professor of Radiology, Department of Radiology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Resident of Radiology, Reproductive Health Research Center, Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran.
Assistant Professor of Obstetrics and Gynecology, Reproductive Health Research Center, Department of Obstetrics & Gynecology, Al-Zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Associate Professor, Department of Biostatistics, Social Determinants of Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.
چکیده
Background: The low level of pregnancy-associated plasma protein A (PAPP-A) has a relationship with unfavorable outcomes in neonates. This study aimed to evaluate the association between the thickness and size of the placenta in singleton pregnant women. Materials and Methods: In this prospective cohort study, ۱۰۲ women were investigated in ۱۸-۲۳ weeks and PAPP-A level at the gestational age in ۱۱-۱۴ weeks with a singleton pregnancy who referred to Al-Zahra Hospital, Rasht, Iran, between ۲۰۱۷ and ۲۰۱۸. Serum PAPP-A of pregnant women was measured in the first trimester of pregnancy. Patients who had PAPP-A ≤ ۰.۵ Multiple of the Median (MOM (were dedicated to an exposed group and others to a non-exposed group. Placental thickness and size were assessed during the second trimester by ultrasound examination and described as abnormal high thickness if the thickness was > ۴ cm or more than ۵۰% of the placental length and abnormally small size when the maximum length was < ۱۰ cm. Then, placental thickness and size were compared between the two groups. Results: PAPP-A levels of > ۰.۵ and ≤ ۰.۵ were recorded in ۶۰ and ۳۴ patients, respectively. Women with low levels of PAPP-A in the first trimester had an increased incidence of abnormal placental thickness in ۱۳ cases and small placental size in ۷ cases, whereas this number was ۱۲ and ۷ cases, respectively, in the other group (P = ۰.۰۲۳). The sensitivity and specificity of PAPP-A < ۰.۵۵ were ۷۲.۳ and ۵۶% for abnormal placental thickness, respectively; the sensitivity and specificity of PAPP-A < ۰.۵۵ were ۶۹.۳ and ۵۷.۱%, respectively, in the assessment of abnormal placenta size. Conclusion Based on the results, the size and thicknesses of the placenta were abnormal in women with a low level of PAPP-A (≤ ۰.۵).کلیدواژه ها
PAPP-A, pregnancy, Placenta, Womenاطلاعات بیشتر در مورد COI
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