Investigation of the Association between a Genetic Variant in MiR-196a-2 Gene and the Risk of Lung Cancer in the Iranian Population
- سال انتشار: 1399
- محل انتشار: فصلنامه گزارش های زیست فناوری کاربردی، دوره: 7، شماره: 3
- کد COI اختصاصی: JR_JABR-7-3_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 304
نویسندگان
Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Introduction: MicroRNAs (miRNAs) play an important role in the expression of their target genes. The single-nucleotide polymorphisms (SNPs) in miRNAs may affect their function and expression. The aim of the present study was to investigate the association between miR-196a2 rs116614913 polymorphism and non-small cell lung cancer (NSCLC) in the Iranian population. Materials and Methods: This case-control study was performed among 103 lung cancer patients and 100 healthy controls. The polymerase chain-reaction restriction fragment length polymorphism (PCR-RFLP) method and direct sequencing were used for miR-196a2 polymorphism genotyping. Statistical analyses were performed using SPSS software and t test method. Results: According to the findings of this study, there was no significant association between rs11614913 polymorphisms and the risk of lung cancer in codominant model (CT vs. CC: OR = 0.67, TT vs. CC: OR = 0.74, CT + CC vs. CC: OR = 1.133), dominant model (CT+TT vs. CC: OR=0.657) and recessive model (TT vs. CC+CT: OR = 0.88). In addition, there was no relationship between the clinicopathological characteristics of patients and controls. Conclusions: In summary, findings indicated no significant association between miR-196a2 rs11614913 polymorphisms and lung cancer in the Iranian population. Further studies with larger sample sizes are recommended to verify these findings.کلیدواژه ها
Lung cancer, Polymorphism, miR-196a2اطلاعات بیشتر در مورد COI
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