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Fabrication and investigation of solid forms of deferasirox for drug development

عنوان مقاله: Fabrication and investigation of solid forms of deferasirox for drug development
شناسه ملی مقاله: CHEMISB03_027
منتشر شده در سومین کنفرانس بین المللی توسعه فناوری در مهندسی شیمی در سال 1399
مشخصات نویسندگان مقاله:

Nasrin Aliasgharlou - Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran
Maryam Ariaeinia - Faculty of Pharmacy, Kermanshah University of Medical Sciences

خلاصه مقاله:
In this work, we aimed to develop various solid forms of Deferasirox (an oral iron chelator, DFX) by theco-crystallization technique to study drug solubility development. In the present work, Tartaric acid,Ascorbic acid, and Formic acid were used as co-formers with ratios of (1DFX: 1 co former) and (1DFX: 2 coformer).The developed solid forms, DFX, and co-formers were characterized by Fourier transform infraredspectrometer. Also, the solubility and dissolution of the obtained samples and DFX were studied.

کلمات کلیدی:
DFX, Solid forms, Tartaric acid, Formic acid, Ascorbic acid

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1181793/