Adherence to Antiretroviral Therapy and Its Determinants in HIV Patients in Mashhad, IRAN, 2018: a Prospective Study
- سال انتشار: 1399
- محل انتشار: مجله پزشکی بالینی، دوره: 7، شماره: 4
- کد COI اختصاصی: JR_RCM-7-4_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 366
نویسندگان
Infectious Disease Specialist, Assistant Professor, Infection Control and hand hygiene Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Students Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad
چکیده
Introduction:Proper adherence to antiretroviral therapy (ART) provides good viral load suppression, while poor adherence can give rise to resistant strains and failure of the treatment. Methods: We performed a prospective cohort study from December 2017 to March 2018. Of 245 patients, 103 of them were compliant with ART. Patient adherence is determined through the self-report method and pill-count method. Pill-count failed, and only self-reports of adherence were used for analysis. In each visit, we gave each patient medication needed for one month’s treatment and asked them to bring back drug-pockets in the next visit. We also ask the number of tablets they did consume in this period. Mean adherence in three months is considered final adherence. Pearson chi-square model was used for analysis.Results: Mean age ± SD was 40 ± 1.36 years. 44.7% were female. 84.5% of patients are considered adherent (≥ 95% of doses were consumed). Married patients had better adherence (p = 0.04). Age, sex, addiction, imprisonment history, intravenous drug usage were not associated with adherence (p > 0.05). We also extracted previews history of treatment cessation and regimen changes. Efavirenz containing regimens had a higher rate of failure (p = 0.001).Conclusion: Although the adherence level was acceptable, the lack of a self-report control method might overestimate adherence.کلیدواژه ها
Antiretroviral therapy, Highly Active, Medication Adherence, Patient Complianceاطلاعات بیشتر در مورد COI
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