Serum Levels of Soluble Fas and Fas Ligand in Iranian Women with Pre-eclampsia
- سال انتشار: 1399
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 9، شماره: 4
- کد COI اختصاصی: JR_RBMB-9-4_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 500
نویسندگان
Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran & Research Committee, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Parasitology department, paramedical school, Ilam University of Medical Science, Ilam, Iran & Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Immunogenetic and Tissue Culture Department, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran & Department of Immunology, School of Medicine, Mazandaran University of Medical Science, Sari, Iran.
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Immunogenetic and Tissue Culture Department, Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Background: The precise responsible mechanism of pre-eclampsia remains controversial however, recent data suggest a main role of the abnormal activation of the adaptive immune system and Apoptosis. In this study, we have measured serum levels of Fas/Fasl as two important members of extrinsic apoptotic pathway in patient with pre-eclampsia. Methods: ۲۰۷ participants including ۹۹ pre-eclampsia patients and ۱۰۸ age and sex-matched normal pregnant women were involved in the case-control study. Plasma sample from each participant was collected and stored at –۲۰ ̊C until batch processing. Serum levels of Fas and Fas ligand were measured by ELISA for each participant including ۹۹ pre-eclampsia patients and ۱۰۸ normal pregnant women. Following a test of statistical normality, nonparametric data were analyzed by Mann-Whitney. Results: sFas levels in case group was significantly higher than controls; ۵۸۴ (۳۹۷-۸۹۲) pg/ml in cases opposed to ۳۴۱ (۲۱۳-۶۰۲) pg/ml in controls (p value< ۰.۰۱). sFasL in pre-eclampsia women was a little lower than controls; ۲۵۵ (۱۷۳-۳۱۸) pg/ml and in case group compared to ۲۶۵.۵ (۱۸۴-۳۸۱.۵) pg/ml in controls. Conclusions: We have found the increased levels of sFas in patients with pre-eclampsia in compare with the healthy pregnant women. It seems that abnormality in sFAS is related with pre-eclampsia.کلیدواژه ها
Pre-eclampsia, Pregnancy, sFAS, sFASL, Apoptosis.اطلاعات بیشتر در مورد COI
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