Reduced live birth rates in frozen versus fresh single cleavage stage embryo transfer cycles: A cross -sectional study

  • سال انتشار: 1399
  • محل انتشار: International Journal of Reproductive BioMedicine، دوره: 18، شماره: 7
  • کد COI اختصاصی: JR_IJRM-18-7_002
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 242
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نویسندگان

Wan Tinn Teh

Department of Obstetrics and Gynaecology, University of Melbourne, The Royal Women’s Hospital, Parkville, Victoria, Australia. Reproductive Services, The Royal Women’s Hospital, Parkville, Victoria, Australia. Melbourne IVF, East Melbourne, Victoria, Aus

Alex Polyakov

Reproductive Services, The Royal Women’s Hospital, Parkville, Victoria, Australia. Melbourne IVF, East Melbourne, Victoria, Australia.

Claire Garrett

Melbourne IVF, East Melbourne, Victoria, Australia.

David Edgar

Reproductive Services, The Royal Women’s Hospital, Parkville, Victoria, Australia. Melbourne IVF, East Melbourne, Victoria, Australia.

John Mcbain

Department of Obstetrics and Gynaecology, University of Melbourne, The Royal Women’s Hospital, Parkville, Victoria, Australia. Reproductive Services, The Royal Women’s Hospital, Parkville, Victoria, Australia. Melbourne IVF, East Melbourne, Victoria, Aus

Peter Rogers

Department of Obstetrics and Gynaecology, University of Melbourne, The Royal Women’s Hospital, Parkville, Victoria, Australia.

چکیده

Background: Studies have suggested that embryo-endometrial developmental asynchrony caused by slow-growing embryos can be corrected by freezing the embryo and transferring it back in a subsequent cycle. Therefore, we hypothesized that live birth rates (LBR) would be higher in frozen embryo transfer (FET) compared with fresh embryo transfers. Objective: To compare LBR between fresh and FET cycles. Materials and Methods: A cross-sectional analysis of 10,744 single autologous embryo transfer cycles that used a single cleavage stage embryo was performed. Multivariate analysis was performed to compare LBR between FET and fresh cycles, after correcting for various confounding factors. Sub-analysis was also performed in cycles using slow embryos. Results: Both LBR (19.13% vs 14.13%) and clinical pregnancy (22.48% vs 16.25%) rates (CPR) were higher in the fresh cycle group (p < 0.00). Multivariate analysis for confounding factors also confirmed that women receiving a frozen-thawed embryo had a significantly lower LBR rate compared to those receiving a fresh embryo (OR 0.76, 95% CI 0.68-0.86, p < 0.00). In the sub-analysis of 1,154 cycles using slow embryos, there was no statistical difference in LBR (6.40% vs 6.26%, p = 0.92) or CPR (8.10% vs 7.22%, p = 0.58) between the two groups. Conclusion: This study shows a lower LBR in FET cycles when compared to fresh cycles. Our results suggest that any potential gains in LBR due to improved embryo-endometrial synchrony following FET are lost, presumably due to freeze-thaw process-related embryo damage.  

کلیدواژه ها

Fresh, Frozen embryo transfer, Live birth, Embryo, Transfer.,   انتقال جنین تازه, منجمد, تولد زنده, جنین, انتقال.

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