Matrix metalloproteinase-9 increases and Interleukin-10 reduces with increase in body mass index in polycystic ovary syndrome: A cross-sectional study

  • سال انتشار: 1399
  • محل انتشار: International Journal of Reproductive BioMedicine، دوره: 18، شماره: 8
  • کد COI اختصاصی: JR_IJRM-18-8_005
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 280
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نویسندگان

Angel Mercy Sylus

Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

Hanumanthappa Nandeesha

Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

Chitra Thiagaraju

Obstetrics and Gynecology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

چکیده

Background: Obesity, inflammation and alterations in matrix metalloproteinase-9 (MMP-9) and nitric oxide (NO) levels are involved in the development of polycystic ovary syndrome (PCOS). Objective: To investigate the relationship of MMP-9, NO and interleukin-10 (IL-10) with the increase in body mass index (BMI) in women with PCOS. Materials and Methods: Sixty two infertile PCOS women were included in the study. Serum levels of NO, IL-10 and MMP-9 were assessed in the women with increase in BMI. Results: MMP-9 was significantly increased (p = 0.029) and IL-10 (p = 0.015) was significantly reduced in obese PCOS subjects compared to those with lesser BMI. MMP-9 levels positively correlated with the duration of infertility (r = 0.253, p = 0.047) and negatively correlated with NO levels (r = - 0.259, p = 0.042). A significant negative correlation between the interleukin-10 levels and the BMI (r = - 0.272, p = 0.033) was also found in the PCOS subjects. Conclusion: MMP-9 levels are increased in obese PCOS women and it is associated with NO levels and the duration of infertility.    

کلیدواژه ها

Body mass index, Interleukin-10, Nitric oxide, Matrix metalloproteinase-9., شاخص توده بدنی, اینترلوکین 10, اکسید نیتریک, متالوپروتئیناز 9-ماتریکس.

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