Bioinformatics evaluation of expression lncRNAs FAM13E and CLRN1-AS1 of targetom has-miR-217 and has-miR-216b signaling pathways and related function of KRAS with colorectal cancer

سال انتشار: 1399
محل انتشار: سومین همایش بین المللی زیست شناسی و علوم زمین
کد COI اختصاصی: BIOLOGY03_035
زبان مقاله: انگلیسی
تعداد مشاهده: 584

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نویسندگان

Zahra Karimi

Department of Genetic, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Nastaran Asghari Moghaddam

Assistant Professor of Genetics, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Atefeh Zamani

Gene Raz Buali, Genetic and Biotechnology Academy, Isfahan, Iran

Nasrin Fatahi

Gene Raz Buali, Genetic and Biotechnology Academy, Isfahan, Iran

چکیده

Colorectal cancer (CRC) is a heterogeneous disease of the colon and rectum that is mainly caused by an adenomatous polyp or adenoma. The estimations of international agencies stratified CRC as the third most common cancer. Long non-coding RNAs (lncRNAs) play critical roles in cell regulation through RNA binding, degradation, transcription, and translation. they contribute to CRC through interaction with DNA, RNA, and proteins as tumorsuppressor or oncogene. Preliminary studies have shown how the expression of microRNAs are in relation with abnormalities whichare characteristics of many diseases such as cancer. Tumor progression, and its response to the treatment are well documented by microRNA profile changes, which in turn suggesting their potential applicability as predictive, diagnostic, and prognostic biomarkers. According to bioinformatic databases and studies of The Cancer Genome Atlas site, two lncRNA FAM138E, lncRNA CLRN1-AS1 were selected to study the colorectal cancer, then searching in different databases like NCBI, mirbase, mirwalk, david to achieve our goals. Finally, we predicted that in people suffering from colorectal cancer, the expression of lncRNA FAM13E and lncRNA CLRN1-AS1 should be raised; therefore, inhibiting the miRNAs 217 and 216b, and ultimately leads in to the increase in theexpression of the KRAS gene and activate the cancer pathways

کلیدواژه ها

Colorectal cancer, lncRNA, miRNA, bioinformatics

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