Correlation of anti-Müllerian hormone levels with metabolic syndrome events in polycystic ovary syndrome: A cross-sectional study
- سال انتشار: 1398
- محل انتشار: International Journal of Reproductive BioMedicine، دوره: 18، شماره: 3
- کد COI اختصاصی: JR_IJRM-18-3_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 218
نویسندگان
Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, ۱۰۴۳۰, Indonesia. Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, ۱۰۴۳۰, Indonesia. Hu
Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, ۱۰۴۳۰, Indonesia.
Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, ۱۰۴۳۰, Indonesia. Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, ۱۰۴۳۰, Indonesia. Hu
Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, ۱۰۴۳۰, Indonesia. Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, ۱۰۴۳۰, Indonesia. Hu
Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, ۱۰۴۳۰, Indonesia. Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, ۱۰۴۳۰, Indonesia. Hu
Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, ۱۰۴۳۰, Indonesia. Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, ۱۰۴۳۰, Indonesia. Hu
Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, ۱۰۴۳۰, Indonesia. Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, ۱۰۴۳۰, Indonesia. Hu
چکیده
Background: Various endocrine disorders have been reported in women of reproductive age, 10% of which is affected by polycystic ovary syndrome (PCOS). Objective: This study aimed to evaluate the correlation of anti-Müllerian hormone (AMH) levels with the metabolic syndrome in patients with PCOS. Materials and Methods: This cross-sectional study employed a consecutive sampling method using medical records from January 2013 to December 2017 at Dr. Cipto Mangunkusumo General Hospital polyclinic and Yasmin in vitro fertilization Clinic (Kencana), Jakarta, Indonesia. The primary outcome of the study was the AMH levels as independent variable correlated with metabolic syndrome. The secondary outcome was also the AMH levels correlated with each PCOS phenotype. The tertiary outcome was each PCOS phenotype as independent variable correlated with metabolic syndrome. Results: Women with phenotype 1 of PCOS had a median AMH level of 13.92 (range: 3.88-34.06) ng/ml. 21% patients had metabolic syndrome, with a median AMH level 7.65 (3.77-20.20) ng/ml, higher than the women without metabolic syndrome (p = 0.38). The most frequent phenotype in women with PCOS was phenotype 4, oligo- or anovulation and polycystic ovary morphology (OA/PCOM) in 41.3%. The most frequent phenotype in women with metabolic syndrome was phenotype 1, OA + PCOM + hyperandrogenism in 56.5%. Conclusion: All PCOS phenotypes exhibited significant correlations with the AMH level. Phenotype 1 (OA + PCOM + hyperandrogenism) was associated with the highest AMH level and was significantly associated with metabolic syndrome.کلیدواژه ها
Anti-Müllerian hormone, Metabolic syndrome, Polycystic ovary syndrome., هورمون آنتی مولرین, سندرم متابولیک, سندرم تخمدان پلیکیستیک.اطلاعات بیشتر در مورد COI
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