The effect of ibuprofen on p53 gene changes in zebrafish (Danio rerio)

In recent decades it has shown toxic effects for a number of drugs and pharmaceutical derivatives. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, and diclofenac are widely used and as a result may often be found in sewage, surface water, and groundwater systems. Ibuprofen, ketoprofen, naproxen, indomethacin, diclofenac, acetylsalicylic acid and phenazone have been found in surface water systems. Since the early 1990s, many drugs have been tested in acute toxicity experiments and found to have detrimental effects on aquatic wildlife. Theseinclude several steroid hormone drugs (estrogen, androgens, progesterone, glucocorticoids), nonsteroidal anti-inflammatory drugs, fibers and statins, neurotoxins (antidepressants and epilepsy), antibiotics and anti-neoplastic drugs and Are cytostatic). Since genetic studies have become very widespread today, in recent years, the burrow has become a well-known organism for studying the function of genes and genetic diseases in vertebrates, due to the fact that the grave Donkeyfish have a number of unique inherent characteristics, including: small body size (length 3 to 4 cm), high reproduction rate (about 100 to 300 larvae in Each mating) and the high speed of its reproductive cycle (the female can lay eggs every two weeks). Also, the breeding and development of zebrafish embryos are external and in the larval stage are clear and well-defined larvae. The p53 gene studied in this study is generally a major tumor suppressor gene that is inactively present in almost all types of cancer. P53 prevents the formation and growth of cancer by regulating multiple pathways, including: The two cell tumors most characteristic of P53 accelerate balance in favor of cell survival or death.