Study the inhibitory effect of some plant origin flavonoids against targetable cancer receptors GRP78 by molecular docking

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 304

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شناسه ملی سند علمی:

IBIS09_055

تاریخ نمایه سازی: 19 اسفند 1399

چکیده مقاله:

Glucose regulated protein 78 kDa (GRP78 ) is a member of heat shock protein 70 kDa (HSP70) family that plays an essential role in protein biosynthesis. Its expression is induced by a variety of environmental and physiological stress conditions such as nutrient deprivation and hypoxia [1]. An overexpression level of GRP78 was observed on thesurface of a variety of cancer cells. The cancer cells protected against apoptotic death by generation of a complex with caspase-7 as antiapoptotic complex. The complex alsomay lead to a progression of cancer or drug resistance [2]. Therefore, GRP78 is a targetable receptor on cancer cells. According the previous experimental result, Epigallocatechin gallate (EGCG) flavonoid is a major component in green tea that has a binding affinity to ATPase domain of GRP78 and prevent the antiapoptotic formation of GRP78-caspase-7 by a competitive inhibition with adenosine tri-phosphate (ATP) molecule [3]. Molecular docking is the most important bioinformatics methods for predict of the binding mode and energy of a protein-ligand complex. Based on these considerations, molecular docking approach was applied to recognize the inhibition potential of 70 flavonoids from eight subclasses for GRP78 were discriminated with considering leader EGCG.

نویسندگان

Fatemeh Barzegar Saloukolaei

Chemometrics Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar ۴۷۴۱۶-۹۵۴۴۷, Iran

Zahra Pahlavan Yali

Chemometrics Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar ۴۷۴۱۶-۹۵۴۴۷, Iran

Mohammad Hossein Fatemi

Chemometrics Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar ۴۷۴۱۶-۹۵۴۴۷, Iran