Preparation of pH/redox responsive biodegradable poly beta amino esters for anticancer drug delivery

Michael Addition Reaction is one of the most powerful methods in organic synthesis for C–C and C–X (X=O,N, S) bond formation. 1 We synthesized biodegradable poly(b-amino ester) (PBAE) polymers in a 2-step reaction procedure (Fig. 1). Firstly, Acrylateterminated Poly(b-amino ester) (Acrylate-PBAE) was obtained via the Michael reaction with 1,4-butandial diacrylate and 4-Amino butanol at room temperature without eny solvent and catalyst. 2 In the second step of the reaction, base polymer was mixed with ethylenediamine overnight at room temperature. 3 In the third step, acrylated mPEG react with acrylate-PBAE with Michael type step polymerization successfully. The confirmation of synthesis and the composition of the prepared PBAEs were determined by 1H nuclear magnetic resonance and infrared spectroscopy data