Preparation of pH/redox responsive biodegradable poly beta amino esters for anticancer drug delivery
محل انتشار: بیست و هفتمین کنفرانس شیمی آلی ایران
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 327
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شناسه ملی سند علمی:
ISOC27_487
تاریخ نمایه سازی: 19 اسفند 1399
چکیده مقاله:
Michael Addition Reaction is one of the most powerful methods in organic synthesis for C–C and C–X (X=O,N, S) bond formation. 1 We synthesized biodegradable poly(b-amino ester) (PBAE) polymers in a 2-step reaction procedure (Fig. 1). Firstly, Acrylateterminated Poly(b-amino ester) (Acrylate-PBAE) was obtained via the Michael reaction with 1,4-butandial diacrylate and 4-Amino butanol at room temperature without eny solvent and catalyst. 2 In the second step of the reaction, base polymer was mixed with ethylenediamine overnight at room temperature. 3 In the third step, acrylated mPEG react with acrylate-PBAE with Michael type step polymerization successfully. The confirmation of synthesis and the composition of the prepared PBAEs were determined by 1H nuclear magnetic resonance and infrared spectroscopy data
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نویسندگان
Fahimeh badparvar
Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia, Iran
Roya salehi
Department of Medical sience, Faculty of Advanced medical Science, Tabriz University, Tabriz, Iran
Ahmad poursattar marjani
Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia, Iran,