Applications of Ni-Biurea/MCM-41 as a powerful heterogeneous nanocatalyst in the Stille reaction

Carbon-Carbon coupling reactions catalyzed by transition-metals are among the most important reactions in the organic synthesis. Stille reaction, which is the cross-coupling of aryl halides and organotin compounds to give biaryl derivatives, is usually catalyzed by palladium.1 However, inorganic supports are generally preferred due to their high stability as the polymeric supports are normally easy to swell under the reaction conditions which significantly affects the catalytic properties.Biaryl products are an important class of compounds that are found in numerous natural products, polymers, and pharmaceuticals.2 In literature, various catalysts are used for the synthesis of biaryl derivatives. In continuation of our previous work,3 we report herein the application of Ni-Biurea/MCM-41 (3) as a powerful heterogeneous nanocatalyst in the synthesis of biaryl (4) via C-C coupling of aryl halide (1) with Ph3SnCl (2) in excellent yields (Fig.1). In addition, the application of Ph3SnCl in the Stille coupling of aryl halides in the presence of Ni-Biurea/MCM-41 is discussed.The structure of catalyst was characterized by different techniques such as TEM, FT‐IR, and BET.

کلیدواژه ها:

Nanocatalyst ، Ni-Biurea/MCM-41 ، Coupling reactions ، Green reaction conditions.