A targeted drug delivery system of anti cancer agents on Folate-Conjugated CM-β-CD and CNCs/APTMS

Drug delivery systems can target the drug to specific tissues,1,2 minimise side effects, overcome solubility problems and toxicity and be tailored to have the appropriate immunogenicity and metabolic stability 3,4. In present research a qualified nanocarrier for targeted drug delivery to tumor cells based on Nanocrystalline cellulose (CNCs) was synthesized. The amino nanoparticles then conjugated with carboxymethyl-β-cyclodextrin (CM-β-CD) by aminopropyltrimethoxysilan (APTMS) as linker. The folic acid (FA) was then embedded into CD cavity via host guest interaction. Doxorubicin (DOX) an anticancer drug was introduced into nanocarier spheres. The properties of the prepared nanocarier were characterized by FT-IR, scanning electron microscope (SEM) and TGA, The in-vitro drug release, drug loading capacity were measured using UV spectroscopy.

کلیدواژه ها:

Nanotechnology ، Targeted drug delivery ، Cyclodextrin ، Cellulose nanocrystals ، Folic acid