Survey Friedel-Crafts reaction of N-aryltrifluoroacetimidoyl chlorides with aromatic compounds

Fluorinated compounds are most important organohalides in natural and medicinal chemistry.1 In the most important drugs which are commercially available, at least one fluorine atom is present such as: antidepressant fluoxetine (Prozac), cholesterol-lowering drug atorvastatin (Lipitor) and the antibacterial ciprofloxacin (Ciprobay).2 The trifluoromethyl group is becoming more and more important in both of agrochemical and pharmaceutical applications because of the influence of fluorine atom on physical, chemical, and physiological properties, stability, and lipophilicity of the molecule. In recent years, reactions of trifluoromethylation have been extensively investigated, in order to synthesis of new organofluorinated drugs.3 Herein, we report a friedel-crafts reaction of N-aryltrifluoroacetimidoyl chlorides 1 and aromatic compounds 2 for synthesis of new N-aryltrifluoroacetimidoyl aromatic compounds 3 (Fig. 1). The FT-IR, 19F-NMR, 1H-NMR and 13C-NMR confirm the structures of the products.

کلیدواژه ها:

Fluorinated compounds ، N-Aryltrifluoroacetimidoyl chlorides ، Friedel-crafts reaction.