Fatemeh Amouee - Department of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran
Nosratollah Mahmoodi - Department of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran
Meysam Pasandideh Nadamani - Department of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran

Sulfathiazole is one of the most important sulfa drugs. It is an organosulfur compound used as a short-acting sulfa drug with antibacterial and antiviral properties. This drug has many uses in the treatment of diseases.1In this research, a new azo derivative of sulfathiazole was synthesized in one-pot via coupling of the corresponding diazonium salt with the salicylaldehyde (Fig.1). The crude product was recrystallized from EtOH to give an orange powder. The resulted azo-aldehyde product was characterized by TLC, M.P, FTIR and NMR. The synthesized azo-aldehyde is a good precursor to utilize as multicomponent one-pot reactions.1-3Antibacterial, antioxidant, anticancer properties and other biological properties in comparison to the standard sulfonamide will also be considered.

Sulfathiazole, Azo compounds, Biological activity