One-pot solvent-free synthesis of 3,4-dihydropyridin-2-(1H)-ones derivatives using a new acidic ionic liquid catalyst

  • سال انتشار: 1398
  • محل انتشار: بیست و هفتمین کنفرانس شیمی آلی ایران
  • کد COI اختصاصی: ISOC27_342
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 255
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نویسندگان

Sara Haghpanah Kouchesfehani

Department of Chemistry, College of Sciences, University of Guilan, ۴۱۳۳۵-۱۹۱۴۱, Rasht, Iran.

Nader Daneshvar

Department of Chemistry, College of science, University of Guilan, University Campus ۲, Iran.

Farhad Shirini

Department of Chemistry, College of Sciences, University of Guilan, ۴۱۳۳۵-۱۹۱۴۱, Rasht, Iran.

Hasan Tajik

Department of Chemistry, College of Sciences, University of Guilan, ۴۱۳۳۵-۱۹۱۴۱, Rasht, Iran.

چکیده

Ionic liquids (ILs) are considered as powerful alternatives to conventional molecular organic solvents and catalysts and have various applications in the field of chemical synthesis. This is due to their particular properties such as non-flammable, recyclable, low vapor pressure, high thermal and chemical stability and the ability to dissolve the wide range of organic compounds 1,2.Dihydropyrimidinones are important for their therapeutic and pharmacological properties. They are used in several calcium channel blockers, antihypertensive drugs and etc. Recently, dihydropyrimidinones have also been considered for the development of new anticancer drugs3.In this study, a new Bronsted acidic ionic liquid based on succinimide was easily prepared and characterized using various techniques. The reagent showed excellent activity in the promotion of the synthesis of 3,4-dihydropyridin-2-(1H)-ones derivatives. The use of this reagent has some important advantages, of which high purity of the products, short reaction times, reusability of the catalyst are the most important ones.

کلیدواژه ها

Ionic liquids, Multicomponent reactions, Biginelli reactions, Knoevenagel condensation, 3,4-dihydropyridin-2-(1H)-ones.

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