An Efficient and One-pot Synthesis of Benzimidazoles Catalyzed via Nano-solid Acid Catalysts

  • سال انتشار: 1398
  • محل انتشار: بیست و هفتمین کنفرانس شیمی آلی ایران
  • کد COI اختصاصی: ISOC27_321
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 406
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نویسندگان

Fariborz Javadi

Department of Chemistry,Faculty of basic Science Babol Noshirvani University Of Technology,Babol, Iran

Setareh Habibzadeh

Department of Chemistry,Faculty of basic Science Babol Noshirvani University Of Technology,Babol, Iran

Mojataba Amininasab

Department of Chemistry, Faculty of Science, University of Kurdistan, Sanandaj, Iran

چکیده

Benzazoles such as benzimidazoles are considered as important class of heterocyclic compounds possessing interesting biological and pharmacological properties as anti-fungal, anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral and anti-cancer agents 1. The most attractive method for the synthesis of benzimidazoles2 is the reaction of 1,2-phenelynediamine with aldehydes 3. Recently reported methods mostly employed homogeneous catalysts which require special work-up and separation technique for the recovery and recycling form the reaction environment. Following our studies in this field4 .In this research, Fe3O4@SiO2@COOH as a new, high efficient and green solid acid catalyst has been prepared and used for the synthesis of benzimidazoles under solvent free conditions. The recovery and reuse of a catalyst is highly desirable during its practical application. We were able to recycle this catalyst five times and use it in reaction, without reducing the efficiency of the product.

کلیدواژه ها

Benzimidazole, Solid acid catalyst, O-Diamine, Aldehyde

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