Synthesis of Novel Spiro-oxindole compounds by Reaction of 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione in green solvent

Most Reactions concerted on useful tools for the synthesis of biologically active compounds. One of these reactions is the multi-step syntheses conducted in a one-pot fashion that can contain various compounds with biological effects. Multicomponent reactions (MCRs) can dramatically reduce the generation of chemical waste and reduce the cost of the starting materials.1 The Uracil, Pyrazole, Pyrazolone and their analogs occupy a unique place in the field of medicinal chemistry as anticancer, anti-inflammatory, antiviral drugs and so all. 2-4 As a part of our continued interest in the synthesis of novel Spiro compounds,5-6 we decided to demonstrate the one-pot reaction of 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolone-1,2-dione 1, 3-methylpyrazol-5-one 2 or 5-amine-3-methyl-pyrazole 3 with 6-aminouracil 4 in the green solvent such as Water, Ethanol and Ethanol/Water (1:1) (scheme 1). The resulting structure 5a were produced in very good yields and the structures were confirmed by the 1H & 13C-NMR and FT-IR spectra,s.

کلیدواژه ها:

Multicomponent reaction ، Spiro-oxindole compound ، 6-aminouracil ، Pyrazolone ، Pyrazole ، Green Solvents