A synthesis of novel (arylthio-ethylidene)indolin-2-one derivatives via S-arylation of oxoindolin-ethanethiolates with aryl halides
محل انتشار: بیست و هفتمین کنفرانس شیمی آلی ایران
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 198
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شناسه ملی سند علمی:
ISOC27_163
تاریخ نمایه سازی: 19 اسفند 1399
چکیده مقاله:
In recent years, Ullmann-type reactions have grown into a versatile tool for access to C−X (X = C, N, O, S, etc.) bonds.1 Although several palladium, nickel, and cobalt catalysts have proven to be highly effective in such coupling processes,2 copper reagents are favorable catalytic systems for C-X bond-forming reactions due to their low cost, low toxicity, and good functional group tolerance.3 Among various cross-coupling reactions, S-arylation is comparatively less studied. However, given the prevalence of C-S bonds in a wide range of pharmaceutical compounds and polymeric materials, it is desirable to find novel catalytic procedures that provide efficient access to such useful organic products. In this investigation, we have reported a practical procedure for the copper-catalyzed S-arylation of triethylammonium [2-oxo-1-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-arylethyl]sulfides, which provides a new route to the synthesis of (Z/E)-3-(2-oxo-2-aryl-1-(arylthio)ethylidene)indolin-2-one derivatives in good yields.
کلیدواژه ها:
نویسندگان
Sara Sheikhi,
Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran
Zohreh Taheri,
Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran
Issa Yavari,
Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran