Synthesis of 2,4,6-triarylpyridine derivatives catalyzed by p-toluene sulfonic acid under solvent-free conditions
محل انتشار: بیست و هفتمین کنفرانس شیمی آلی ایران
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 112
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شناسه ملی سند علمی:
ISOC27_067
تاریخ نمایه سازی: 19 اسفند 1399
چکیده مقاله:
The heterocyclic compounds are very useful intermediates for the development of molecules in pharmaceutical or biological interest. The 2,4,6-triarylpyridines are applied as the useful intermediate in the synthesis of drugs, herbicides, insecticides, desiccants and surfactants and also prominent building blocks in supramolecular chemistry. So, designing of the new procedure for this transformation is highly desirable.1-3In this work the reaction of aldehyde, acetophenone and ammonium acetate by using p-toluene sulfonic acid (TsOH) as efficient catalyst to afforde the 2,4,6-triarylpyridines under solvent-free conditione was reported.After completion of reactin, the progress was monitored by TLC. Than, the reaction mixture was cooled to room temperature and the precipitated solid was collected, washed with cold ethanol, to give the pure product in excellent yields. Finally, melting point, 1H NMR, and FT-IR techniques were recognized the structure of compounds.
کلیدواژه ها:
نویسندگان
Hossein Naeimi
Department of Organic Chemistry, Faculty of Chemistry, University, of Kashan, Kashan ۸۷۳۱۷, I.R. Iran;
Zahra Namnabat
Department of Organic Chemistry, Faculty of Chemistry, University, of Kashan, Kashan ۸۷۳۱۷, I.R. Iran;