Synthesis of thiazepine derivatives using 2-(1, 3-dioxo-1H-inden-2(3H)- ylidene) malononitryl and thiosemicarbazone
عنوان مقاله: Synthesis of thiazepine derivatives using 2-(1, 3-dioxo-1H-inden-2(3H)- ylidene) malononitryl and thiosemicarbazone
شناسه ملی مقاله: ISOC27_058
منتشر شده در بیست و هفتمین کنفرانس شیمی آلی ایران در سال 1398
شناسه ملی مقاله: ISOC27_058
منتشر شده در بیست و هفتمین کنفرانس شیمی آلی ایران در سال 1398
مشخصات نویسندگان مقاله:
Mahdieh Sajadi, - Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Ali Darehkordi, - Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Abdolhassan Namvar - Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
خلاصه مقاله:
Mahdieh Sajadi, - Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Ali Darehkordi, - Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Abdolhassan Namvar - Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Thiazepines and their derivatives are one of the most important heterocyclic compounds, due to the anticonvulsant, antiviral, anticancer, anti-HIV and antitumor effects.1-3 In this study firstly, 2-(1,3-dioxo-1H-indene-2(3H)-yilidene) malononitrile was synthesized from reaction of ninhydrin with malononitril in the ethanol as a solvent at room temperature. Then this intermediate was used for synthesis of thiazepine derivatives using thiosemicarbazone derivatives (Scheme 1). Purification all of the compounds were achieved by recrystallization and were further identified by FT-IR, 1H-NMR, 13C-NMR spectra analysis.
کلمات کلیدی: Thiosemicarbazone, Malononitryl, Ninhydrin, Thiazepine
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1163866/