Biological profile of boronic acid multivalent functionalized MoS2 nanosheets

Two-Dimensional MoS2 has attracted high attention owing to its unique physicochemical properties as well as biocompatibility and biodegradability.1-3 Surface functionalization of MoS2 nanosheet through the incorporation of functional groups with the ability of attachments to the biological systems significantly improves its biological activity.4, 5 In this work, boronic acid-functionalized 2D MoS2 was synthesized and its covalent multivalent interactions at different biointerfaces including bacteria, nematode and diabetic wounds were investigated. The boronic acid-functionalized 2D MoS2 (MoS2-B) was synthesized by stepwise polymerization of glycidol and conjugation of boronic acid to the surface of MoS2 sheets (Fig1). MoS2-B showed strong interactions with the membrane of bacteria and body of nematode and destroyed both microorganisms in a short time. Due to the strong antibacterial and antinematode activity and its ability to make a thin-film on the surface of wounds, MoS2-B was applied for the diabetic wound healing. Taking advantage of the straightforward synthesis, antibacterial and antinematode activities as well as healing the diabetic wounds, MoS2-B is a promising candidate for a broad range of future biomedical applications

کلیدواژه ها:

Molybdenum disulfide ، Boronic acid ، Antibacterial ، Antinematode and Wound healing.