Interferon- Gamma- Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly
- سال انتشار: 1397
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 7، شماره: 1
- کد COI اختصاصی: JR_RBMB-7-1_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 234
نویسندگان
Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
چکیده
Background: Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of frailty. Interferon-gamma (INF-γ) is an understudied proinflammatory cytokine in frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects. Methods: INF-γ, neopterin, and nitric oxide (NO) levels were measured in 80 participants. Results: Both pre-frail and frail subjects had significantly higher levels of INF-γ, neopterin and lower levels of NO than the control group. These biomarkers were associated with the risk of frailty with significant odds ratio. Conclusions: Elevated INF-γ levels in frail subjects may activate the GTP-CH1 pathway. Elevated neopterin and reduced NO levels correlated with an active GTP-CH1 pathway. The risk of frailty increased with elevated INF-γ and neopterin and decreased with elevated NO levels.کلیدواژه ها
Frailty, GTP-CH1 pathway, INF-γ.اطلاعات بیشتر در مورد COI
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