A Survey on the Role of Interleukin-10 in Breast Cancer: A Narrative
- سال انتشار: 1397
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 7، شماره: 1
- کد COI اختصاصی: JR_RBMB-7-1_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 269
نویسندگان
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Science, Yazd, Iran.
Department of Immunology, School of Medicine, Arak university of Medical Sciences, Arak, Iran.
Department of Pediatric Dentistry, Arak university of Medical Sciences, Arak, Iran.
Department of Endodontic, Arak university of Medical Sciences, Arak, Iran.
Department of Restorative and Esthetic, Arak University of Medical Sciences, Arak, Iran.
Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
چکیده
Interleukin (IL)-10, a multifunctional immune-regulatory cytokine with both immunosuppressive and anti-angiogenic functions, is produced by immune cells including macrophages, T lymphocytes, and natural killer cells. Among other effects, IL-10 promotes tumor cell proliferation and metastasis via immunosuppression. Interleukin-10-mediated immunosuppression is aided by synthesis of tumor necrosis factor, IL-1, IL-12, and chemokines, and down regulation of the surface co-stimulatory molecules CD80 and CD86 on tumors. Interleukin-10 also promotes IL-6 expression and synthesis, which causes cell proliferation via B cell lymphoma-2 (Bcl-2) upregulation and changes the proliferation/apoptosis equivalence toward neoplastic cell proliferation. Moreover, IL-10 inhibits tumorigenesis via down-regulation of VEGF, IL-1b, TNF-α, IL-6, and MMP-9. Interleukin-10 also inhibits nuclear factor-κB (NF-κB) translocation. Interleukin-10 has been reported to have both tumor-promoting and -inhibiting properties. It seems that IL-10 agonists and antagonists may have therapeutic effects via different mechanisms. Moreover, IL-10 gene polymorphisms may determine breast cancer susceptibility.کلیدواژه ها
Breast cancer, Cytokine, IL-10اطلاعات بیشتر در مورد COI
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