Status of FAS and FAS Ligand Gene Polymorphisms in Patients wi th Breast Cancer in Northeastern IRAN
- سال انتشار: 1397
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 7، شماره: 1
- کد COI اختصاصی: JR_RBMB-7-1_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 308
نویسندگان
Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran & Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam Davarpanah Tanha Ghochan
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran & Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
چکیده
Background: The First apoptosis signal (FAS) and First apoptosis signal ligand (FASL) genes initiate the apoptosis pathway, playing a central role in the tumor growth and metastasis. Gene polymorphisms including -1377 G/A in the promoter region of FAS and -844 C/T in the promoter region of FASL have shown to change the transcription activities of these genes. Methods: In this study we evaluated association of these polymorphisms with risk of metastasis of breast cancer, in a population selected from Mashhad, Iran. A total of 115 patients with breast cancer and 115 controls were recruited in this case-control study. Polymerase Chain Reaction-based Restriction Fragment Length Polymorphism (PCR-RFLP) was applied for genotyping on extracted DNA from participant’s blood. Unconditional logistic regression was used to estimate cancer risk by calculating odds ratios (OR) and their 95% confidence intervals (95% CIs). Results: There was no significant association between these genetic polymorphisms and breast cancer risk. Additionally, our results showed no significant influence from the above mentioned gene polymorphisms on metastasis of breast cancer. Conclusions: These results suggest that the FAS-1377G/A and FASL-844 C/T gene polymorphism don’t have much influence on the susceptibility to metastasis of breast cancer in northeastern Iranian population. Therefore, we suggest to investigate impact of other candidate gene polymorphisms on metastasis of breast cancer for future research.کلیدواژه ها
Breast cancer, Fas Ligand, Fas receptor, Gene polymorphism, Metastasisاطلاعات بیشتر در مورد COI
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