Amelioration of Lipid Peroxidation and Antioxidant Enzymes Status in the Serum and Erythrocytes of Phenylhydrazine-Induced Anemic Male Rats: The Protective Role of Artichoke Extract (Cynara scolymus L.)
محل انتشار: فصلنامه طب دامی ایران، دوره: 14، شماره: 3
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 184
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شناسه ملی سند علمی:
JR_IJVM-14-3_009
تاریخ نمایه سازی: 20 دی 1399
چکیده مقاله:
BACKGROUND: Hemolytic anemia is a disorder characterized by the premature erythrocytes destruction. Phenylhydrazine (PHZ) induces oxidative stress and reactive oxygen species (ROS) formation, which causes hemolytic anemia. Cynara scolymus due to its antioxidant compounds, has been used for various therapeutic purposes in traditional medicine. OBJECTIVES: The present study was designed to evaluate the effects of Cynara scolymus extract on PHZ -induced anemia in male rats. METHODS: Hemolytic anemia was induced by intraperitoneal injection of PHZ (40 mg/kg) for 2 days. Thirty male Wistar rats were divided into five groups. Group 1 (normal control). Group 2 (anemic control) received only PHZ. The groups 3 to 5 were injected with 100, 200, 400 mg/kg of the Cynara scolymus by gavage, respectively, daily from day 2 to day 15 after PHZ administration. At the end of the treatment period, blood samples were collected to assess hematological parameters, malondialdehyde (MDA) level and antioxidant enzymes activity, including superoxide dismutase (SOD) and total antioxidant capacity (TAC) in the serum and erythrocytes. RESULTS: In anemic rats, serum and erythrocytes MDA level increased, but SOD and TAC activity de- creased significantly when compared with control group (p ≤ 0.05). These changes were ameliorated by treat- ment with Cynara scolymus at different doses (p ≤ 0.05). Also, improvement in several hematological param- eters was observed in anemic rats after administration of Cynara scolymus (p ≤ 0.05). CONCLUSIONS: Cynara scolymus extract exhibits protective property against PHZ-induced oxidative stress presumably due to antioxidative activity.
کلیدواژه ها:
نویسندگان
Milad Alahmoradi
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
Samad Alimohammadi
Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
Hadi Cheraghi
Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
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