Comparison of Using Misoprostol with or without Letrozole in Abortion Induction: A Placebo-Controlled Clinical Trial
- سال انتشار: 1397
- محل انتشار: فصلنامه زنان و مامایی و سرطانهای زنان، دوره: 3، شماره: 2
- کد COI اختصاصی: JR_JOGCR-3-2_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 200
نویسندگان
Obstetrics & Gynecology Department, Medicine Faculty, Iran University of Medical Sciences, Tehran, Iran
Obstetrics & Gynecology Department, Medicine Faculty, Iran University of Medical Sciences, Tehran, Iran
Obstetrics & Gynecology Department, Medicine Faculty, Iran University of Medical Sciences, Tehran, Iran
چکیده
Aims The rate of induced abortion is growing worldwide. In this study, we aimed at comparing using misoprostol with or without Letrozole in abortion. Materials and Methods In this placebo-controlled trial, 46 women with a gestational age of fewer than 20 weeks, who were candidates of legal abortion, were selected by simple randomization sampling method and randomly assigned into two groups. Drug group received 10mg daily Letrozole (4 tablets of 2.5mg) for 3 days prior to taking Misoprostol and the placebo group received daily placebo (4 tablets with the exact appearance of Letrozole) with the same instructions. After 3 days, Misoprostol was given to all the participants based on their gestational ages. The data were analyzed by SPSS 16 software, using independent sample t-test and Chi-square test. Findings 21 women (45.7%) had a successful complete abortion, and curettage was needed for 25 women (54.3%). Successful abortion rate was significantly higher in the group receiving Letrozole (78.3%) than the group receiving placebo (13.0%; p=0.0001). Mean induction-abortion interval was 22.61±7.721 hours in the drug group and 24.09±8.251 hours in the placebo group, which was not significantly different (p> 0.05). There was no significant difference between the two groups in terms of vaginal bleeding and adverse effects. Conclusion Using 10mg daily Letrozole for 3 days followed by oral Misoprostol results in a significantly higher rate of complete abortion compared with placebo in women with a gestational age of less than 20 weeks.کلیدواژه ها
Letrozole, Misoprostol, Induced Abortionاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.