Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients with Breast Cancer
- سال انتشار: 1400
- محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 16، شماره: 1
- کد COI اختصاصی: JR_IJP-16-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 543
نویسندگان
Department of Pathology, Cancer Institute of Iran, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Department of Pathology, Cancer Institute of Iran, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Department of Pathology, Cancer Institute of Iran, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Department of Pathology, Cancer Institute of Iran, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Iran National Tumor Bank, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
Iran National Tumor Bank, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background & Objective: Nowadays, actin-binding proteins such as Villin and Gelsolin have been considered to be associated with aggressive tumors. This study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients with breast cancer. Methods: The included population consisted of 40 confirmed cases of female breast cancer (including 20 patients with breast cancer along with axillary lymph node metastasis and 20 patients without axillary lymph node metastasis). Expression of Villin and Gelsolin genes was evaluated using Real-time PCR and pre-designed primers. Results: The mean expression level of Villin in groups with and without axillary lymph node metastasis was 3.33±1.35 and 0.87±0.88, respectively (p < 0.001). The mean Gelsolin expression levels in both groups (with and without axillary lymph node metastasis) were 4.13±2.40 and 1.00±0.35, respectively (p < 0.001). The significant relationships were independent of individuals’ age. Conclusion: Patients with axillary lymph node metastasis may express significant higher level of Villin and Gelsolin gens.کلیدواژه ها
Breast cancer, Gelsolin, Metastasis, Villinاطلاعات بیشتر در مورد COI
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