The relationship between hot-wet temperament in Iranian Traditional Medicine (ITM) and Non-alcoholic Fatty Liver Disease (NAFLD) from systems biology point of view

Introduction and Objectives: Iranian Traditional Medicine (ITM) has a holistic approach on disease and treatment and has always had a lack of molecular biology evidence; ITM has a common approach with systems biology which considers the life as a system consisting the components and their interactions. The aim of this study is to establish a connection between ITM and conventional medicine through expressing ITM in the form of modern molecular biology.Materials and Methods: In this study, GEO۲R software was used to find the genes for Non-alcoholic Fatty Liver Disease (NAFLD) and the genes for hot-wet temperament was obtained by a previous study using proteomics. Then the genes of NAFLD were compared with the genes of hot-wet temperament to find the potential common genes between them and the pathways related to these common genes were extracted.Results: Based on this comparison, three genes were common between NAFLD and hot-wet temperament. It was found that the pathways associated with these common genes are important in NAFLD and its progression.Conclusion: These results could explain why people with hot-wet temperament develop NAFLD.

کلیدواژه ها:

Iranian Traditional Medicine (ITM) ، Systems biology ، Non-Alcoholic Fatty Liver Disease (NAFLD) ، Temperament