A review of Electrospun Nanofiber Poly L-Lactic Acid scaffold application for angiogenesis in biomedical researches

Introduction: Tissue engineering is one of the most practical fields of regenerative medicine that integrates engineering and biology sciences to substitute, restore, and cure injured tissues. However, tissue engineering is not yet a true clinical reality due to some complications. One of the main problems is insufficient vascularization among the construct. Scaffolds which are artificial extracellular matrices play a crucial role in the survival of tissues.Description: Electrospun Poly l-lactic acid (PLLA) scaffolds made of interconnected pores with suitable mechanical attributes can be manufactured in sheet or tubular form; also it would be easily coated by other compounds like hydroxyapatite and many other inductive agents. PLLA shows high capacity in terms of composition with vast range of materials. These features made it an interesting scaffold for many tissue engineering types of research.Discussion and conclusion: The exploration of an efficient strategy to significantly improve angiogenesis besides practical features of PLLA leads scientists to conduct many investigations. This review will provide an overview of PLLA roles and effects in angiogenesis researches, like bone tissue engineering and diabetic wound investigations.

کلیدواژه ها:

Angiogenesis ، Poly l-lactic acid ، Tissue engineering ، Scaffold