Nutrigenomics studies and Evaluation of Irisin level Affected by the Expression of Skeletal Muscle Genes

سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 433

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شناسه ملی سند علمی:

ICIBS01_195

تاریخ نمایه سازی: 2 آذر 1399

چکیده مقاله:

Introduction: The point view of nutrigenomics, foods have signals that can affect metabolic pathways, control of homeostasis, gene expression, and protein production. Irisin production is a metabolic pathway that results from the proteolytic breakdown of the FNDC5 (Fibronectin type III domain containing 5) which is secreted by the skeletal muscle as an exercise hormone during exercise and is dependent on PGC-1 gene expression. The aim of this study is to review the effects of diet on the expression of some genes and the production of skeletal muscle proteins.Description: In studies effects of diets on skeletal muscle genes expression, Rats were fed with high-carbohydrate diet (HCD), high-fat diet (HFD), and high-protein diet (HPD). They were evaluated of lipid profile, FNDC5 and PGC-1 expression in muscle and protein levels of Irisin. The results showed that HFD and HCD were associated with decreased of FNDC5, PGC-1 and Irisin level. HPD prevented reductions of FNDC5, PGC-1 expression and Irisin levels, compared to the control group. although no differences were observed for total cholesterol and HDL levels.Discussion and conclusion: The molecular structure of a food can have important effects on gene expression, protein, and metabolism and enable specific signaling pathways. so small changes in structure of food have a profound effect on the sensitive pathways that are activated. In conclusion, it was found that the HPD type of diet can effective on mRNA of muscle cells and change FNDC5, PGC-1 expression and Irisin levels. Therefore, HPD seems to be the most appropriate diet to achieve high levels of irisin and thermogenesis and today, using the HPD diet is a good strategy for treat obesity and as a protein supplements in athletes diet it improve their performance.

نویسندگان

Alieh Abdolrezaei

Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

Hashem Nayeri

Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

Ali Mohammad Ahadi

Department of Genetic, School of Science, Shahr-e-kord University, Shahr-e-Kord, Iran