The growth inhibitory capacity of Thymus daenensis Celak essential oil on MDA-MB-231 cancer cells
محل انتشار: کنگره بین المللی علوم زیست پزشکی اصفهان
سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 263
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شناسه ملی سند علمی:
ICIBS01_140
تاریخ نمایه سازی: 2 آذر 1399
چکیده مقاله:
Finding new natural cytotoxic agents against human breast cancer cells is valuable. Essential oils are complex mixtures of volatile compounds with various biological properties. Thymus daenensis Celak (Avishan-e-denaei in Persian) is one of the endemic Thymus species in Iran. Yet cytotoxic properties of Thymus daenensis Celak essential oil (TDEO) against breast cancer cells is unclear. In this study, the cytotoxic activity of TDEO against MDA-MB-231 human breast cancer cell line was evaluated by MTT assay. Results showed that TDEO induces cell death in the cancer cells. The anti-proliferative activity of TDEO was time and dose dependent and more pronounced against MDA-MB-231 cancer cell compared to L929 normal cells. Further analysis is required to understand the type of cell death and underlying cellular and molecular anticancer properties of TDEO.
کلیدواژه ها:
نویسندگان
Sasan Vakili
Department of Biological Science and Biotechnology, Faculty of Science, University of Kurdistan, Sanandaj, Iran
Raheleh Shakeri
Department of Biological Science and Biotechnology, Faculty of Science, University of Kurdistan, Sanandaj, Iran
Jalal Khorshidi
Department of Horticultural Science and Engineering, Research Center of Medicinal Plants Breeding and Development, University of Kurdistan, Sanandaj, Iran