Risk of Infertility and celiac disease; a case report and literature review

Background: Celiac disease as an immune-mediated disorder that is commonly associated with intestinal symptoms due to genetically-susceptible to gluten, can also impact the reproductive system, resulting in increased risk of infertility, impairing embryo implantation, repeated miscarriages, premature deliveries. Material and Method: We searched PubMed for English-language articles published between 2000 and 2020, containing information about the risk of infertility and celiac disease, and studies that evaluating the prevalence of undiagnosed celiac disease in subjects with infertility. Result: According to prospective serologically-based studies, over 4% of females with reproductive disorders or pregnancy difficulties have celiac disease without any manifestations, or ultimately, fatigue associated with iron-deficiency anemia. Subsequently, amenorrhea, delayed onset of menarche, early menopause and reduced fertility in females may possibly be the primary clinical feature that finally results in a diagnosis of celiac disease.Case: The case is a 28 years old lady who had referred to a gynecologist department because of infertility for 3 years. Diagnosis of celiac disease and administration of a strict gluten-free diet for this patient result in pregnancy. Conclusion: Serological screening for suspicious cases with few or no symptoms such as unexplained infertility seems to be a cost effective method. As in females with infertility and untreated celiac disease, gluten-free diet solely, can lead to successful pregnancy.

کلیدواژه ها:

Infertility ، Celiac disease ، Gluten-free diet ، case report