The role of wild-type p53 in cancer

Introuduction: p53 protein or guardian of genome is the most famous tumor inhibitor of classic type. since more than 50% of human cancers are due to loss of function within p53 due to mutations. this protein has vital role in genomic stability and Tumor suppression through the induction of apoptosis and seizure of the cell cycle, aging, inhibiton of angiogenesis.Materials and methods: In this review article tried to use data’s of google scholar, pumed, nih to conserned about p53 gene role in treatment of cancers.Results: It is now known distruption of p53 mechanisms by affecting and paying attention to carcinogenic mutations causes growth and Tumors progression. The p53 mutation acts as dominant inhibitor compared to wild type of p53.Wild type of p53 (wt) protein can inhibit oncogene_induced cellular transformation.Conclusions: In the current review article p53 regulatory mechanism and also p53 mediated therapeutic strategies for the treatment of malignant cancers are one of the expected factors, for chemotherapy providing a new strategy is for eliminating the negative effect of. p53 mutation within the (wt).

کلیدواژه ها:

apoptosis ، cancer ، p53