The effect of different long non-coding RNAs on MDR۱ drug resistance gene in cancer

سال انتشار: 1399
محل انتشار: کنگره بین المللی علوم زیست پزشکی اصفهان
کد COI اختصاصی: ICIBS01_046
زبان مقاله: انگلیسی
تعداد مشاهده: 328

نویسندگان

MSc Student of Medical Biotechnology, Faculty of Modern Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran

Tahereh Abdali

BSc. Public Biology, Payame Noor University of Isfahan, Isfahan, Iran

چکیده

Introduction: cancer is one of the main causes of death all over the world. There are various aspects to the mechanism of resistance to chemotherapy, one of which is multidrug resistance in cancer. Multidrug resistance proteins (MRPs), known as ABC transporter proteins, responsible for the efflux of anti-cancer drugs through the cell membrane by ATP hydrolysis. Emerging evidence showed that long non-coding RNAs (LncRNAs) took a section in the regulation of MDR۱ expression. Long non-coding RNAs (lncRNAs) widely exist in human various tissues, they larger than ۲۰۰ nt and lncRNAs could form complex with corresponding target genes, promote or inhibit the degradation and translation of target genes and have been shown to play crucial roles in drug resistance, small part of functional lncRNAs have been well characterized with diverse regulatory roles in cellular processes, such as cell proliferation and migration.Description: This is a review study Collected by reviewing articles related to LncRNA and its effect on drug resistance with the Keywords "MDR۱" OR "Multidrug Resistance" and "LncRNA" OR "Long noncoding RNA" from ۲۰۱۵ onwards, from Google Scholar and Pubmed it has been compiled and written. ۲۵ articles were collected, that Of these ۹ articles were excluded because of lack of subject relevance And only ۱۶ studies were used. The inclusion criteria were all articles that examined the effect of LncRNA on MDR۱.Discussion and conclusion Inclusion: Different studies have shown that LncRNAs such as DANCR, HOTAIR, PVT۱, H۱۹, SNHG۵, FENDRR, tsRMST, MALAT۱, BC۰۳۲۵۸۵, LINC۰۰۹۶۸, UCA۱, Nrf۲, and TUG۱ can affect the MDR۱ drug resistance gene. Therefore, understanding the effect of LncRNAs on the MDR۱ resistance gene could be an effective step in decreasing drug resistance in cancer patients.

کلیدواژه ها

LncRNA, MDR۱, Cancer

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