Bioinformatics evaluation of hsa-miR-1289 signaling pathways and its associated rs10277413 function in patients with Non-small-cell lung cancer

  • سال انتشار: 1399
  • محل انتشار: کنگره بین المللی علوم زیست پزشکی اصفهان
  • کد COI اختصاصی: ICIBS01_029
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 609
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نویسندگان

Eman Koosehlar

Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran

Farzaneh Ahmadi Shapoorabadi

Department of Biotechnology, Faculty of Biological Science and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran

Hassan Mohabatkar

Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran

چکیده

Introduction & Objectives: Non-small-cell lung cancers (NSCLCs) are the most common lung cancers and account for more than 80% of all lung cancers. Overexpression of EGFR has been reported and implicated in the pathogenesis of many human malignancies, including NSCLC.Materials & Methods: To get more information we used NCBI, miRNASNP, miRBase, miRWALK2.0, DAVID databases and KEGG pathway as the bioinformatics tools.Results: Investigations at the rs10277413 locus indicated that T allele altered to A and G, which may effect on function of the miRNA associated with this region. Finally, hsa-miR-1289 as one of the most important miRNAs related to EGFR and given the confirmation of the role of hsa-miR-1289 in NSCLC through bioinformatics databases, this miRNA selected for this analysis.Conclusion: The studies due to rs10277413 have shown that when the SNP locus is in the mutant A or G allele, the miRNA binds to it less strongly than the wild T allele. So when this SNP occurs, hsa-miR-1289 has less inhibitory effect on it and EGFR is transcribed more. Due to role EGFR in cell proliferation, we predicted that a person with this harmful polymorphism is more susceptible to NSCLC by increasing the expression of the EGFR.

کلیدواژه ها

Non-small-cell lung cancer, hsa-miR-1289, NSCLC, EGFR, KEGG pathway

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