Aloe Vera/Chitosan Hydrogels Containing Vancomycin for Wound Healing Applications

  • سال انتشار: 1399
  • محل انتشار: سومین کنگره ملی شیمی و نانوشیمی از پژوهش تا فناوری
  • کد COI اختصاصی: ICCNRT03_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 578
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نویسندگان

Maryam Naeimi

Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran

Arefe Karami

Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Reyhaneh Pasdar

Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Mitra Naeimi

Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran

چکیده

The aim of this research is to develop a dressing with desired antibacterial activity, water maintaining ability and structural properties for wound healing and skin regeneration. In the present study, a porous dressing was prepared from chitosan and aloe vera by freeze- drying. Vancomycin was added to the scaffolds to introduce antibacterial activity. SEM images revealed that mean pore diameter of pure chitosan scaffold was 114±25 μm. Mean pore diameter was increased when aloe vera was added and reached to 174±32 μm. Histogram of chitosan porous scaffolds showed wide distribution of pores, however, histogram of C70A30 scaffold showed narrow distribution of pores. Water uptakeability of the samples was higher for chitosan/aloe vera (C/A). This data indicated the potential of the porous structures to be used as highly absorbing wound dressing material. Antibacterial activity of the chitosan/aloe vera samples was proved against Staphylococcus aureus according to the antibacterial test. The results showed that vancomycin loaded chitosan/aloe vera porous scaffolds have potential use in wound dressing

کلیدواژه ها

chitosan, aloe vera, wound dressing, porous

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