Ethanolic extract of Iris songarica rhizome attenuates methotrexate-induced liver and kidney damages in rats

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 422

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شناسه ملی سند علمی:

JR_AJP-10-4_005

تاریخ نمایه سازی: 31 تیر 1399

چکیده مقاله:

Objective: The long-term sequelae of methotrexate (MTX) remain the major cause of concern for both patients and therapists. Therefore, new approaches to decrease MTX side effects are needed. The study was carried out to evaluate the effects of Iris songarica Schrenk (IS) rhizome extract against MTX-induced hepatic and renal injuries in rats. Materials and Methods: Forty male Wistar rats were randomly divided into five groups (n=8) including control, MTX, IS50, IS150 and IS300. Control and MTX groups were only treated orally with saline; whereas, IS50, IS150 and IS300 groups were treated with IS extract at three different doses (50, 150, and 300 mg/kg, respectively). Besides, the MTX and experimental groups were received a single dose of MTX (20 mg/kg) intraperitoneally on day 4. On the ninth day, animals were sacrificed, blood transaminases, urea and creatinine were assessed and the concentration of malondialdehyde (MDA) and the activity of super-oxide dismutase (SOD) were determined in both liver and kidney tissues. Moreover, hepatic and renal damages were evaluated histopathologically. Results: MTX by increasing oxidative stress (MDA) and decreasing antioxidant capacity (SOD) induced hepatic and renal damages as confirmed by biochemical and histological parameters analyses. However, treatment with IS caused significant improvements in hepatic and renal histological architectures and SOD activity (p<0.01) along with reducing liver enzymes, urea, creatinine and MDA (p<0.01). Conclusion: The results of the present study showed that IS extract through antioxidant and probably anti-inflammatory activities, could effectively limit MTX-induced hepatic and renal injuries in rats.

نویسندگان

Hesam Moodi

Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran

Mehran Hosseini

Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran

Mohammad Reza Abedini

Cellular and Molecular Research Center, Department of Pharmacology, Birjand University of Medical Sciences, Birjand, Iran

Mahsa Hassanzadeh-Taheri

Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

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  • Abdel-Daim MM, Khalifa HA, Abushouk AI, Dkhil MA, Al-Quraishy SA. ...
  • Ahani A, Hassanzadeh-Taheri M, Hosseini M, Hassanpour-Fard M. 2017. Antinociceptive ...
  • Akther N, Andrabi K, Nissar A, Ganaie S, Chandan BK, ...
  • Asci H, Ozmen O, Ellidag HY, Aydin B, Bas E, ...
  • Ataie Z, Mehrani H, Ghasemi A, Farrokhfall K. 2019. Cinnamaldehyde ...
  • Ayatollahi SA, Moein MR, Kobarfard F, Choudhary MI. 2004. Two ...
  • Becciolini A, Biggioggero M, Favalli EG. 2016. The role of ...
  • Bu T, Wang C, Meng Q, Huo X, Sun H, ...
  • Bertino JR. 2000. Methotrexate: historical aspects. In: Cronstein BN, Bertino ...
  • De S, Kundu S, Chatterjee U, Chattopadhyay S, Chatterjee M. ...
  • El-Twab SMA, Hussein OE, Hozayen WG, Bin-Jumah M, Mahmoud AM. ...
  • Hassanzadeh-Taheri M, Hassanpour-Fard M, Doostabadi M, Moodi H, Vazifeshenas-Darmiyan K, ...
  • Hassanzadeh-Taheri M, Hosseini M, Hassanpour-Fard M, Ghiravani Z, Vazifeshenas-Darmiyan K, ...
  • Hassanzadeh-Taheri M, Hosseini M, Salimi M, Moodi H, Dorranipour D. ...
  • Heidari R, Ahmadi A, Mohammadi H, Ommati MM, Azarpira N, ...
  • Kalantari H, Asadmasjedi N, Reza Abyaz M, Mahdavinia M, Mohammadtaghvaei ...
  • Khafaga AF, El-Sayed YS. 2018. Spirulina ameliorates methotrexate hepatotoxicity via ...
  • King C, Killens WR. 2012. A guide to species irises: ...
  • Kurutas EB. 2016. The importance of antioxidants which play the ...
  • Maestá I, Nitecki R, Horowitz NS, Goldstein DP, de Freitas ...
  • Mehrzadi S, Fatemi I, Esmaeilizadeh M, Ghaznavi H, Kalantar H, ...
  • Moein MR, Khan SI, Ali Z, Ayatollahi SA, Kobarfard F, ...
  • Moghadam AR, Tutunchi S, Namvaran-Abbas-Abad A, Yazdi M, Bonyadi F, ...
  • Nurgali K, Jagoe RT, Abalo R. 2018. Adverse effects of ...
  • Ozogula B, Kisaoglua A, Turanb MI, Altunerc D, Senerd E, ...
  • Pour MG, Mirazi N, Seif A. 2019. Treatment of liver ...
  • Shah VV, Lin EJ, Reddy SP, Wu JJ. 2016. Chapter ...
  • Taylor P, Balsa Criado A, Mongey A-B, Avouac J, Marotte ...
  • Weinblatt ME. 2018. Methotrexate: who would have predicted its importance ...
  • Xu Q, Higgins T, Cembrowski GS. 2015. Limiting the testing ...
  • Zhang J, Chen R, Yu Z, Xue L. 2016. Superoxide ...
  • نمایش کامل مراجع