The Survival of Patients with t(15;17)(q22;q12) Positive Acute Promyelocytic Leukemia: A Study in North-East of Iran
- سال انتشار: 1399
- محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 15، شماره: 3
- کد COI اختصاصی: JR_IJP-15-3_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 424
نویسندگان
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background & Objective: Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (AML). Here, our objective was to ascertain the survival of patients with this leukemia in north-east of Iran. Methods: Survival rates of 42 APL patients with t(15;17)(q22;q12) were assessed. Clinical information was obtained from archived medical records. Statistical analysis was performed by SPSS 18 software using log-ranked test and Kaplan Maier survival analysis. Results: Females and males comprised 49% and 51%, respectively. The mean age at diagnosis was 34.3 14.1 years old. During the study period, 17 demises occurred in males, while this number was 7 in females. The mean survival of patients (month) was 23.22 3.57 (95% CI: 16.21 30.2). The five-year survival rate obtained 30%. Regarding demographic and clinical features, the highest rates of 5-year survival were recorded in patients with 20-35 years old (47.6%), males (51%), white blood cell count 140 /l (100%). Conclusion: Younger age, lower WBC count and higher platelet count were significantly associated with longer survival in AML patients with t(15;17)(q22; q12).کلیدواژه ها
Acute myeloid leukemia, Acute promyelocytic leukemia, Blood cancer, Survival, t(15, 17)(q22, q12)اطلاعات بیشتر در مورد COI
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