Effect of Diphenhydramine Gargling on Sore Throat in Patients Undergoing Cataract Surgery with Laryngeal Mask Insertion

  • سال انتشار: 1398
  • محل انتشار: مجله پزشکی بالینی، دوره: 6، شماره: 4
  • کد COI اختصاصی: JR_RCM-6-4_006
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 450
دانلود فایل این مقاله

نویسندگان

Mohsen Sabermoghaddam

Assistant Professor Anesthesiology, Lung Disease Research Center , Mashhad University of Medical Sciences, Mashhad, Iran.

Elham Bakhtiari

Assistant Professor of Pharmacology, Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohammad Alipour

Associate Professor of Anesthesiology and Critical care, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

چکیده

Intoduction: Sore throat is a common postoperative complication in patients undergoing general anesthesia. Several factors contribute to this complication, and the airway management method plays a pivotal role in this regard. The present study aimed to assess the effect of diphenhydramine gargling on sore throat in patients undergoing cataract surgery with laryngeal mask insertion. Methods: This placebo-controlled, double-blind, clinical trial was conducted on two groups of intervention and control. The patients in the intervention group gargled 8 cc (20 mg) of diphenhydramine diluted to 20 cc with normal saline 20 minutes before anesthesia induction. The control group patients gargled 20 cc of normal saline 20 minutes before anesthesia induction. The score of sore throat severity was determined based on the visual analogue scale during recovery three, six, 12, and 24 hours postoperatively. Results: Initially, 176 candidates of eye surgery using laryngeal mask airway (LMA) were enrolled in the study, and three patients were excluded from the intervention group due to withdrawal. In the intervention group, 36 patients (42.9%) were female, and 48 patients (57.1%) were male. In the control group, 46 patients (52.3%) were female, and 42 patients (47.7%) were male. The mean age of the subjects was 59.5±16.74 and 57.94±15.74 years in the intervention and controls groups, respectively. No significant differences were observed between the groups in terms of age and gender (P=0.53 and P=0.29, respectively). The mean score of pain severity was 0.3±0.14 and 1.7±0.14 in the intervention and control groups, respectively, which indicated a significant difference between the groups at each measurement point (P< 0.001). However, the reported pain severity scores were not correlated with age, gender, mask size, and duration of surgery. Conclusion: Gargling 20 milligrams of diphenhydramine suspension 20 minutes prior to LMA insertion in the patients undergoing eye surgery significantly reduced the post-anesthesia sore throat compared to the control group. Moreover, sore throat had no associations with the age, gender, duration of surgery, and mask size of the patients.

کلیدواژه ها

Cataract Surgery, Diphenhydramine Chloride, Laryngeal mask airway, Postoperative Sore Throat

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.