The Protective Effect of Celecoxib on CA1 Hippocampal Neurons and Oxidative Stress in a Rat Model of Parkinson’s disease Effect of Celecoxib on CA1 Hippocampal Neurons and Oxidative Stress

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 430

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شناسه ملی سند علمی:

EMAA18_016

تاریخ نمایه سازی: 5 اردیبهشت 1399

چکیده مقاله:

Several studies point to an important role of neuroinflammation in Parkinson s disease (PD). Cognitive and memory impairments have been known in the early stages of PD. Objectives: In the present study we examined the effects of celecoxib (CLX), a selective inhibitor of cyclooxygenase-2 (COX-2), on hippocampus cell loss, passive avoidance memory and antioxidant status in a rat model of PD. We used the subcutaneous injection of 2.5 mg/kg/48h rotenone (ROT) for 4 weeks for induction of PD in a male Wistar rat. Animals were randomized to 4 groups (n=12): Control, sham, PD and PD+CLX group that receive celecoxib (20 mg/kg/day) for 4 weeks. Passive avoidance memory evaluated. We also determined protective effect of CLX on number of CA1 neurons in Nissl and TUNEL staining. Total antioxidant capacity (TAC) and malondialdehyde (MDA) a marker of lipid peroxidation in hippocampus assessed. Our findings indicated administration of CLX increase the passive avoidance memory (P < 0.05), and by decrease in apoptosis caused increase in viable pyramidal neurons in CA1 hippocampus (P < 0.01). On the other hand CLX markedly reduced MDA level and increased TAC in hippocampus of PD model animal (p < 0.05). It seems CLX with anti-inflammatory and antiapoptotic effect could prevented from neurons loss and memory impairment which induced in PD.

نویسندگان

Maryam Sarbishegi

Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan,IR Iran.Department of Anatomy, School of Medicine, Zahedan University of Medical Sciences,Zahedan, IR Iran

Hamidreza Mahmoudzadeh-sagheb

Infection Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran. Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran

Zahra Heidari

Infection Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran. Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran

Farzaneh Baharvand

Department of Anatomy, School of Medicine, Zahedan University of Medical Sciences,Zahedan, IR Iran