Experimental production and initial imaging of [۱۸F]-۱۴-Fluoro-۶-thia-heptadecanoic acid ([۱۸F]-FTHA) for myocardial performance [Persian]
- سال انتشار: 1385
- محل انتشار: مجله پزشکی هسته ای ایران، دوره: 14، شماره: 2
- کد COI اختصاصی: JR_IRJNM-14-2_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 226
نویسندگان
Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran
چکیده
Introduction: [۱۸F]-۶-thia-۱۴-fluoro-heptadecanoic acid ۳b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications. Methods: [۱۸F] Benzyl-۱۴-Fluoro-۶-thia-heptadecanoate ۲b was prepared in no-carrier-added (n.c.a) form from Benzyl-۱۴-tosyloxy-۶-thia-heptadecanoate ۱ in one step at ۹۰C in Kryptofix۲.۲.۲/[۱۸F] and acetonitrile as the solvent followed by Silica column chromatography. The radiolabeled ester ۲ was then hydrolyzed to yield [۱۸F]-۶-thia-۱۴-fluoro-heptadecanoic ۳b. The final solution was concentrated using C۱۸ SPE system and administered to normal rats for biodistribution as well as co-incidence imaging studies. Results: The synthesis took ۱۵ min with overall radiochemical yield of ۱۵-۲۵% (EOS) and chemical-radiochemical purity more than ۹۴%. Automation was performed using a two-pot synthesis. The best imaging time was shown to be ۱۴۰-۱۸۰ minutes post injection. Conclusions: Using this procedure a fast, reliable, automated synthesis for the cordial PET tracer, i.e. [۱۸F]-FTHA can be obtained without HPLC purification step.کلیدواژه ها
PET imaging, Radiochemical, Fluorine-۱۸, myocardiumاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.