Characterization of Immunophenotypic Aberrancies in Adult and Childhood Acute Lymphoblastic Leukemia: Lessons from Regional Variation

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 361

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شناسه ملی سند علمی:

JR_IJP-15-1_001

تاریخ نمایه سازی: 21 فروردین 1399

چکیده مقاله:

Background & Objective:Although the antigen expression patterns of acute lymphoblastic leukemia (ALL) are well known, this study attempted to evaluate commonly used immune markers for immunophenotyping of acute leukemia to set the minimum of necessary diagnostic panels by flow cytometry.Methods:This study evaluated 89 patients referred from all over the country to the Iranian Blood Transfusion Organization (IBTO) in Tehran from 2013 to 2015. We compared the immunophenotype patterns of childhood and adult ALLs including 69(77.5%) B-cell lymphoblastic lymphoma (B-LBL), 2(2.2%) Burkitt’s lymphoma (BL), and 18(20.2%) T-cell lymphoblastic lymphoma (T-LBL) cases using flowcytometry with broad antibody panel.Results:CD19 and CD79a were the most frequent markers for B-LBL while CD7 was the most sensitive marker in T-LBL; the frequency of CD7, CD3, and CD5 antigens were 100%, 38.9%, and 88.9%, respectively. TdT+/CD34+ was significantly higher in adult B-LBLs than children, which indicates blast cells are more immature in adults. In addition, CD10 and cCD79a were significantly higher in children with B-LBL like as CD5 and CD8 in children with T-LBL. Aberrant phenotypes including CD13, CD33, CD7, and CD117 were found in 7(10.1%) cases of B-LBL. These phenotypes were CD117, HLA-DR, and CD33 in 7(38/9%) cases of T-LBL. Expression of CD117 aberrant myeloid antigen was significantly more associated with T-LBL than with B-lineage ALL.Conclusion:Significant differences were observed in antigen-expression patterns between adult and childhood ALLs. Further studies are needed to correlate specific markers with recurrent cytogenetic abnormalities and prognosis with therapeutic response.

نویسندگان

Mitra Rezaei

Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran|High Institute for Research and Education in Blood Transfusion Medicine, Iranian Blood Transfusion

Sandra Refoua

High Institute for Research and Education in Blood Transfusion Medicine, Iranian Blood Transfusion Organization, Tehran, Iran

Najme Esfandiari

Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Masoud Shamaei

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis, Tehran, Iran

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  • Banihashem A, Ghasemi A, Tavasolian L. Association of cytogenetics and ...
  • Pui C-H, Robison LL, Look AT. Acute lymphoblastic leukaemia. The ...
  • Mousavi SM, Pourfeizi A, Dastgiri S. Childhood cancer in Iran. ...
  • Shadi Kolahdoozan MD M, Alireza Sadjadi MD M, Radmard AR, ...
  • Dastgiri S, Fozounkhah S, Shokrgozar S, Taghavinia M, Asvadi Kermani ...
  • Alebouyeh M. Current status of pediatric oncology in Iran. Arch ...
  • Udomsakdi-Auewarakul C, Promsuwicha O, Tocharoentanaphol C, Munhketvit C, Pattanapanyasat K, ...
  • McPherson RA, Pincus MR. Henry s clinical diagnosis and management ...
  • Paredes‐Aguilera R, Romero‐Guzman L, Lopez‐Santiago N, Burbano‐Ceron L, Monte CD, ...
  • Gorczyca W. Flow Cytometry in Neoplastic Hematology: Morphologic--Immunophenotypic Correlation. London: ...
  • Seegmiller AC, Kroft SH, Karandikar NJ, McKenna RW. Characterization of ...
  • Basturk A, Akinci S, Hacibekiroglu T, Guney T, Kutlucan A, ...
  • Supriyadi E, Veerman AJ, Purwanto I, Cloos J. Myeloid antigen ...
  • Sarma A, Hazarika M, Das D, Kumar Rai A, Sharma ...
  • Gorczyca W. Flow Cytometry in Neoplastic Hematology: Morphologic--Immunophenotypic Correlation: CRC ...
  • Hussein S, Gill KZ, Sireci AN, Colovai AI, Small T, ...
  • Salem DA, El-Aziz SMA. Flowcytometric immunophenotypic profile of acute leukemia: ...
  • Chughtai O, Chughtai A. Aberrant Expression of CD Markers in ...
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