Effects of aerobic exercise intensity on glucagon-like peptide-۱ (GLP-۱) and insulin resistance (IR) in obese rats

Obesity increases the risk of a variety of chronic diseases due to the hormones involved in being overweight. Decreases in the quantity and quality of physical activity due to changes in modern lifestyles and changes in diet toward high-energy foods lead to weight gain and obesity.Glucagon-like peptide-۱ (GLP-۱) are of the incretin hormones secreted from the intestine upon ingestion of food to increase insulin secretion, regulate blood sugar and improvements insulin resistance (IR); however, there is limited information on the effects of different intensities of aerobic training on GLP-۱ and IR. The purpose of this study was to investigate the effects of aerobic exercise intensity on GLP-۱and IR in obese rats.This study is an in vitro study. Thirty-two male Wistar rats were divided into ۴ groups: three group’s different intensity of aerobic training (high, moderate and low intensity) and one group’s control. After ۸ weeks of different intensity of aerobic training, plasma concentration of glucose, insulin, HOMA-IR and GLP-۱ were calculated. Data was statistically analyzed by dependent t-test, Analysis of variance (ANOVA) with a ۰.۰۵ significance level.After eight-week of interventions, body weight, BMI, insulin, blood glucose and HOMA-IR in high, moderate and low intensity of aerobic training were significantly lower than oil group (P=۰.۰۰۱). Moderate and high intensity of aerobic training compared with low intensity significantly caused reduction in insulin, blood glucose, HOMA-IR, and GLP-۱.The findings of this study showed that moderate and high intensity of aerobic training causes GLP-۱ secretion is impaired, thus its improving can cause a decrease in insulin resistance and blood glucose regulation.

کلیدواژه ها:

Aerobic training ، glucagon-like peptide-۱ ، Insulin resistance