Synthesis of Stable phosphorus ylide based on Three-Component Reaction between Triphenylphosphine and Diethyl acetylene dicarboxylate in the Presence of Celecocxib

Stable phosphorus ylide was obtained in excellent yields from the reactions between triphenylphosphine and diethyl acetylenedicarboxylates, in the presence of celecoxib. These stable ylide exists in solution as a mixture of the two geometrical isomers as a result of restricted rotation around the carbon– carbon partial double bond resulting from conjugation of the ylide moiety with the adjacent carbonyl group.Rotation is slow on the NMR time scale at ambient. The structure of products was elucidated by IR, 1HMR, and 13CNMR spectra.

کلیدواژه ها:

stable phosphorus ylides ، three-component reaction ، Dialkyl acetylenedicarboxylates ، three-component reaction