HAIR GROWTH IN RAT MODEL BY USING OF ETHANOLIC EXTRACT OF EUCHEUMA COTTONII

Hair has various physiological functions, including protection from the elements and dispersion of sweat-gland products. It it also psychosocial important, and patients with hair loss (alopecia) often deeply suffer. Demand for medications that alter hair growth and appearance has led to a multibillion-dollar industry and thus far few natural effective products are available. For the purpose of ascertaining natural products which possess hair growing activity, we looked over onto ethanolic and aqueous extracts of E. cottonii. Hair follicles have greatly been regarded as intriguing but largely separate and non-essential adjuncts to skin. Hair follicle epithelial stem cells and their contribution to skin healing have attracted particular attention. Oral treatments commenced soon after shaving the dorsal interscapular area of healthy male Sprague-Dawley rats. Microscopic observations of skin were performed. This study showed ethanolic extract of E. cottonii increased the rate of wound contraction and epithelization when compared to positive and negative control groups. The ethanolic extract of E.cottonii was %02 more effective than aqueous extraction. Ethanolic extract of this seaweed enhanced hair growth by higher proliferative activity. The extraction also possesses several antioxidant compounds, which may be responsible for the accelerated hair growth and wound healing. We demonstrated for the first time in the present study that this seaweed extracts revealed faster healing and hair growth even when compared with positive control group.

کلیدواژه ها:

Seaweed (Eucheuma cottonii) ، Wound healing ، hair follicle ، hair growth