An Investigation into Biocompatibility and Biodegradability of PLLA Nano-Scaffold using Electrospinning

Tissue engineering provides a new research field. In this new research field, cell, scaffold and biomolecules are used to create an extended landscape in restoration, repair and maintenance of tissues. In this study, nano properties of polymer scaffolds for tissue engineering purposes are discussed.PLLA polymer scaffold was created using electrospinning technique ,chloroform solvent and DMF. Then the surface of scaffold was treated to improve biodegradability. Scaffold was investigated in terms of surface morphological characteristics, biodegradablility, porosity and pore size. For this purpose, porosity measurements with Archimedes law, biodegradablility test and scanning electron microscopy study were performed. Degradation rate of scaffold is high because there are small pores and scaffold degradation rate is proportional to the time. The most important factor in the biodegradable scaffold is direct relationship between the amount of biodegradable scaffold and water absorption by the scaffold. Evaluation of cell growth and increased cell growth in the presence of nano-scaffold showed the confirmed the biocompatibility of nano-scaffold. It indicated high porosity of 57/89 percent and internal tissue growth.The overall results showed that PLLA nano-scaffold polymer synthesized with electrospinning technique is a good candidate for tissue engineering.

کلیدواژه ها:

Nano-scaffolds ، Electrospinning ، Biocompatibility ، Biodegradability